Evidence reference
Common health issues: what the evidence actually studied
This guide maps 66 common health issues to the potential benefits and compounds studied for each, graded by the strength of the evidence — from strong human trials through to preclinical signals and, just as importantly, where the evidence is insufficient or negative. It exists so researchers can choose materials based on what has actually been studied, not on marketing claims.
Research cut-off: 30 September 2026. This is a research reference for laboratory materials, not medical advice and not a recommendation for human use.
66
Conditions reviewed
59
Compounds cross-referenced
114
Cited sources
How to read it
Evidence is graded per condition, not per compound
A compound can have strong human evidence for one condition and insufficient evidence for another. The guide grades each compound against each specific issue, so "none established" is reported as honestly as a strong result.
Strong / moderate human evidence
Persuasive or reasonably supportive human clinical data for the stated population and outcome.
Limited or mixed human evidence
Human data exists but with material limitations, inconsistency, or narrow applicability.
Preclinical only
Animal or laboratory findings only. A mechanism to investigate — not evidence of human benefit.
Insufficient or negative
No convincing benefit found, or larger trials found against benefit. Reported as plainly as positive results.
Condition index
Browse the 66 conditions covered
Compound detail, evidence grades, supplement context and cited sources for each condition are available to signed-in members.
Injury, joints and recovery
- 01Ligament sprains and tears
- 02Tendon injuries and tendinopathy
- 03Muscle strains and tears
- 04Osteoarthritis
- 05Rheumatoid and other inflammatory arthritis
- 06Cartilage damage and meniscal injury
- 07Bursitis
- 08Back and neck pain
- 09Bone healing and stress fractures
- 10Post-surgical recovery
- 11Wound healing and chronic ulcers
- 12Exercise soreness and recovery
Cognition, mood and neurological symptoms
Sleep
Energy and fatigue
Weight and metabolic health
Muscle and physical performance
Gut and digestion
Skin, hair and connective tissue
Sexual and hormonal health
Healthy ageing and immune concerns
Members see the full evidence detail
The members' guide includes, for every condition: the compounds studied with per-condition evidence grades, human and preclinical findings, combination evidence, relevant nutritional context, and links to the cited sources — plus a guided compound selector that ranks candidates by evidence strength.